Thiosemicarbazones as New Antitumor Compounds
نویسنده
چکیده
The search of new compounds with medicinal applications is promoting important therapeutic advances and generates a new scientific multidisciplinary field where chemistry, pharmacy and biomedicine overlap together with other specialities. Thiosemicarbazones are some of the studied compounds. These sulfur-containing organic substances exhibit an interesting biological activity, which has been studied for more than fifty years1. In this sense, it is worth mentioning the efforts carried out in the cancer research. During the middle 1960s some of these derivatives showed high antitumor activity in different assays2-3. This fact encouraged to perform the first clinical trials, early stopped due to the unexpected low activity in humans4.
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